STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe-Reference-Cited by-同舟云学术

STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Published:2023-03-06 Issue:4 Volume:25 Page:1284-1295
ISSN:1099-5129
Container-title:EP Europace
language:en
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Author:

Grehn Melanie¹^ORCID,Mandija Stefano²^ORCID,Miszczyk Marcin³^ORCID,Krug David¹^ORCID,Tomasik Bartłomiej⁴⁵^ORCID,Stickney Kristine E⁶,Alcantara Pino⁷^ORCID,Alongi Filippo⁸,Anselmino Matteo⁹¹⁰^ORCID,Aranda Ricardo Salgado¹¹^ORCID,Balgobind Brian V¹²,Boda-Heggemann Judit¹³,Boldt Leif-Hendrik¹⁴,Bottoni Nicola¹⁵,Cvek Jakub¹⁶^ORCID,Elicin Olgun¹⁷^ORCID,De Ferrari Gaetano Maria⁹^ORCID,Hassink Rutger J¹⁸^ORCID,Hazelaar Colien¹⁹,Hindricks Gerhard²⁰^ORCID,Hurkmans Coen²¹^ORCID,Iotti Cinzia²²^ORCID,Jadczyk Tomasz²³²⁴^ORCID,Jiravsky Otakar²⁵^ORCID,Jumeau Raphaël²⁶^ORCID,Kristiansen Steen Buus²⁷,Levis Mario²⁸^ORCID,López Manuel Algara²⁹^ORCID,Martí-Almor Julio³⁰^ORCID,Mehrhof Felix³¹^ORCID,Møller Ditte Sloth³²^ORCID,Molon Giulio³³^ORCID,Ouss Alexandre³⁴^ORCID,Peichl Petr³⁵^ORCID,Plasek Jiri³⁶,Postema Pieter G³⁷^ORCID,Quesada Aurelio³⁸^ORCID,Reichlin Tobias³⁹^ORCID,Rordorf Roberto⁴⁰^ORCID,Rudic Boris⁴¹^ORCID,Saguner Ardan M⁴²,ter Bekke Rachel M A⁴³^ORCID,Torrecilla José López⁴⁴^ORCID,Troost Esther G C⁴⁵⁴⁶⁴⁷,Vitolo Viviana⁴⁸^ORCID,Andratschke Nicolaus⁴⁹^ORCID,Zeppenfeld Katja⁵⁰^ORCID,Blamek Slawomir⁴^ORCID,Fast Martin²^ORCID,de Panfilis Ludovica⁵¹^ORCID,Blanck Oliver¹,Pruvot Etienne⁵²^ORCID,Verhoeff Joost J C²^ORCID

Affiliation:

1. Department of Radiation Oncology, University Medical Center Schleswig-Holstein , Arnold-Heller-Strasse 3, Kiel 24105 , Germany

2. Department of Radiotherapy, University Medical Center Utrecht , Heidelberglaan 100, Utrecht 3584 CX , The Netherlands

3. IIIrd Radiotherapy and Chemotherapy Department, Maria Skłodowska-Curie National Research Institute of Oncology , Ul. Wybrzeze Armii Krajowej, Gliwice 44102 , Poland

4. Department of Radiotherapy, Maria Skłodowska-Curie National Research Institute of Oncology , Ul. Wybrzeze Armii Krajowej, Gliwice 44102 , Poland

5. Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdansk , M. Sklodowskiel-Curie 3a, Gdansk 80210 , Poland

6. Research Support Office, University Medical Center Utrecht , Heidelberglaan 100, Utrecht 3584 CX , The Netherlands

7. Department of Radiation Oncology, Hospital Clínico San Carlos, Faculty of Medicine, University Complutense of Madrid , Profesor Martin Lagos, Madrid 28040 , Spain

8. Department of Advanced Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, University of Brescia , Via San Zeno in Monte 23, Verona 37129 , Italy

9. Division of Cardiology, Cardiovascular and Thoracic Department, ‘Città della Salute e della Scienza’ Hospital , Via Giuseppe Verdi 8, Torino 10124 , Italy

10. Department of Medical Sciences, University of Turin , Via Verdi 8, Torino 10124 , Italy

11. Electrophysiology Unit, Department of Cardiology, Hospital Clínico San Carlos Madrid , Professor Martin Lagos, Madrid 28040 , Spain

12. Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam , Meibergdreef 15, Amsterdam 1105AZ , The Netherlands

13. Department of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg , Theodor-Kutzer-Ufer 1-3, Mannheim 68167 , Germany

14. Department of Rhythmology, Charité—University Medicine Berlin , Charitéplatz 1, 10117 Berlin , Germany

15. Cardiology Arrhythmology Center, AUSL-IRCCS di Reggio Emilia , Via Amendola 2, Reggio Emilia 42100 , Italy

16. Department of Oncology, University Hospital and Faculty of Medicine , Listopadu 1790, Ostrava Poruba 70852 , Czech Republic

17. Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern , Freiburgstrasse 18, Bern 3010 , Switzerland

18. Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University , Heidelberglaan 100, Utrecht 3584 CX , The Netherlands

19. Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre+ , P. Debyelaan 25, Maastricht 6229 HX , The Netherlands

20. Department of Electrophysiology, Heart Center Leipzig, University of Leipzig , Struempellstrasse 39, Leipzig 04289 , Germany

21. Department of Radiation Oncology, Catharina Hospital , Michelangelolaan 2, Eindhoven 5623 EJ , The Netherlands

22. Radiation Oncology Unit, Clinical Cancer Centre, AUSL-IRCCS di Reggio Emilia , Via Amendola 2, Reggio Emilia 42100 , Italy

23. Division of Cardiology and Structural Heart Diseases, Medical University of Silesia , Ul. Poniatowskiego 15, Katowice 40055 , Poland

24. Interventional Cardiac Electrophysiology Group, International Clinical Research Center, St. Anne’s University Hospital Brno , Brno , Czech Republic

25. Cardiocenter, Hospital Agel Trinec Podlesi and Masaryk University , Konska 453, Trinec 73961 , Czech Republic

26. Department of Radio-Oncology, Lausanne University Hospital , Rue du Bugnon 21, Lausanne 1011 , Switzerland

27. Department of Cardiology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, Aarhus 8200 , Denmark

28. Department of Oncology, University of Torino , Via Giuseppe Verdi 8, Torino 10124 , Italy

29. Department of Radiation Oncology, Hospital del Mar, Universitat Pompeu Fabra, Institut Hospital del Mar d'Investigacions Mèdiques , Paseo Maritim 25-29, Barcelona 08003 , Spain

30. Department of Cardiology, Hospital del Mar, Universitat Pompeu Fabra, Institut Hospital del Mar d'Investigacions Mèdiques , Paseo Maritim 25-29, Barcelona 08003 , Spain

31. Department for Radiation Oncology, Charité—Universitätsmedizin Berlin , Charitéplatz 1, 10117 Berlin , Germany

32. Department of Oncology, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, Aarhus 8200 , Denmark

33. Department of Cardiology, IRCCS Sacro Cuore Don Calabria Hospital , Via San Zeno in Monte 23, Verona 37129 , Italy

34. Department of Cardiology, Catharina Hospital , Michelangelolaan 2, Eindhoven 5623 EJ , The Netherlands

35. Department of Cardiology, Institute for Clinical and Experimental Medicine , Videnska 9, Prague 14000 , Czech Republic

36. Department of Cardiovascular Medicine, University Hospital Ostrava , Listopadu 1790. Ostrava Poruba 70852 , Czech Republic

37. Department of Cardiology, Amsterdam UMC, University of Amsterdam , Meibergdreef 15, Amsterdam 1105AZ , The Netherlands

38. Arrhythmia Unit, Department of Cardiology, Consorcio Hospital General Universitario de Valencia , Av Tres Cruces 2, Valencia 46014 , Spain

39. Department of Cardiology, Inselspital, Bern University Hospital, University of Bern , Freiburgstrasse 18, Bern 3010 , Switzerland

40. Cardiac Intensive Care Unit, Arrhythmia and Electrophysiology and Experimental Cardiology, Fondazione IRCCS Policlinico San Matteo , Camillo Golgi Avenue 5, Pavia 27100 , Italy

41. Department of Medicine I, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg , Theodor-Kutzer-Ufer 1-3, Mannheim 68167 , Germany

42. Arrhythmia Unit, Department of Cardiology, University Hospital Zurich , Ramistrasse 71, Zurich 8006 , Switzerland

43. Department of Cardiology, Maastricht University Medical Center , P. Debyelaan 25, Maastricht 6229 HX , The Netherlands

44. Department of Radiation Oncology, Hospital General Valencia , Av Tres Cruces 2, Valencia 46014 , Spain

45. Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden , Fetscherstraße 74, Dresden 01307 , Germany

46. OncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus. Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf , Fetscherstrasse 74, Dresden 01307 , Germany

47. Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf , Bautzner Landstr. 400, Dresden 01328 , Germany

48. National Center of Oncological Hadrontherapy (Fondazione CNAO) , Strada Campeggi 53, Pavia PV27100 , Italy

49. Department of Radiation Oncology, University Hospital of Zurich , Ramistrasse 71, Zurich 8006 , Switzerland

50. Unit of Clinical Electrophysiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333 ZA , The Netherlands

51. Bioethics Unit, Azienda Unità Sanitaria Locale—IRCCS , Via Amendola 2, Reggio Emilia 42100 , Italy

52. Heart and Vessel Department, Service of Cardiology, Lausanne University Hospital and University of Lausanne , Rue du Bugnon 21, Lausanne 1011 , Switzerland

Abstract

AbstractThe EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions’ experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://academic.oup.com/europace/article-pdf/25/4/1284/49919707/euac238.pdf

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