Brugada syndrome and syncope: a practical approach for diagnosis and treatment

Author:

Mascia Giuseppe12,Bona Roberta Della12ORCID,Ameri Pietro12ORCID,Canepa Marco12ORCID,Porto Italo12ORCID,Parati Gianfranco34ORCID,Crotti Lia345,Brignole Michele367ORCID

Affiliation:

1. Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy

2. Department of Internal Medicine, University of Genoa, Genova, Italy

3. Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Milan, Italy

4. Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

5. Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Milan, Italy

6. Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, Faint & Fall Programme, Ospedale San Luca, Piazzale Brescia 20, 20149 Milan, Italy

7. Department of Cardiology, Arrhythmologic Centre, Ospedali del Tigullio, Lavagna, Italy

Abstract

Abstract Syncope in patients with Brugada electrocardiogram pattern may represent a conundrum in the decision algorithm because incidental benign forms, especially neurally mediated syncope, are very frequent in this syndrome similarly to the general population. Arrhythmic syncope in Brugada syndrome typically results from a self-terminating sustained ventricular tachycardia or paroxysmal ventricular fibrillation, potentially leading to sudden cardiac death. Distinguishing syncope due to malignant arrhythmias from a benign form is often difficult unless an electrocardiogram is recorded during the episode. We performed a review of the existing literature and propose a practical approach for diagnosis and treatment of the patients with Brugada syndrome and syncope.

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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