Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation

Author:

Shen Mengyu1,Zhang Huidong2,Shen Wei3ORCID,Zou Zhenyu2,Lu Shuguang1,Li Gang1,He Xuesong4,Agnello Melissa5,Shi Wenyuan4,Hu Fuquan1,Le Shuai1ORCID

Affiliation:

1. Department of Microbiology, Third Military Medical University, Chongqing 400038, China

2. Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China

3. Department of Medical Laboratory, Chengdu Military General Hospital, Chengdu 610083, China

4. The Forsyth Institute, 245 First St, Cambridge, MA 02142, USA

5. School of Dentistry, University of California, Los Angeles, CA 90095, USA

Funder

National Natural Science Foundation of China

National Key Research and Development Program

NIH

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference59 articles.

1. Selection-driven gene loss in bacteria;Koskiniemi;PLoS Genet.,2012

2. Repeated, selection-driven genome reduction of accessory genes in experimental populations;Lee;PLoS Genet,2012

3. Microbial minimalism: genome reduction in bacterial pathogens;Moran;Cell,2002

4. Spontaneous deletion of a 209-kilobase-pair fragment from the Escherichia coli genome occurs with acquisition of resistance to an assortment of infectious phages;Tanji;Appl. Environ. Microbiol.,2008

5. Pyomelanin-producing Pseudomonas aeruginosa selected during chronic infections have a large chromosomal deletion which confers resistance to pyocins;Hocquet;Environ. Microbiol.,2016

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