ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer

Author:

Nguyen Nam-phuong D1,Deshpande Viraj1,Luebeck Jens2,Mischel Paul S345,Bafna Vineet1

Affiliation:

1. Computer Science and Engineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

2. Bioinformatics and Systems Biology Program, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

3. Ludwig Institute for Cancer Research, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

4. Department of Pathology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

5. Moores Cancer Center, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA

Funder

National Science Foundation

National Institutes of Health

Extreme Science and Engineering Discovery Environment

National Institute for Neurological Diseases and Stroke

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference58 articles.

1. Global burden of cancers attributable to infections in 2012: a synthetic analysis;Plummer;Lancet Glob. Health,2016

2. The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability;Duensing;Cancer Res.,2002

3. The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis;Yim;Cancer Res. Treat.,2005

4. Hepatitis B virus X protein (HBx) modulates oncogene YAP via CREB to promote growth of hepatoma cells;Zhang;Hepatology,2012

5. Viral infections as a cause of cancer (review);Carrillo-Infante;Int. J. Oncol.,2007

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