Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

Author:

Md Yusof Md Yuzaiful12ORCID,Smith Eve M D34ORCID,Ainsworth Sammy5,Armon Kate6,Beresford Michael W34,Brown Morgan5,Cherry Lindsey7,Edwards Christopher J8ORCID,Flora Kalveer9,Gilman Rebecca10,Griffiths Bridget11,Gordon Caroline10ORCID,Howard Paul5,Isenberg David12ORCID,Jordan Natasha13,Kaul Arvind14ORCID,Lanyon Peter1516,Laws Philip M17,Lightsone Liz18,Lythgoe Hanna19,Mallen Christian D20ORCID,Marks Stephen D2122,Maxwell Naomi5,Moraitis Elena2324,Nash Clare25,Pepper Ruth J26,Pilkington Clarissa23,Psarras Antonios27,Rostron Heather128ORCID,Skeates Jade29,Skeoch Sarah29,Tremarias Dalila5,Wincup Chris30,Zoma Asad31,Vital Edward M12ORCID

Affiliation:

1. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital , Leeds, UK

2. NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust , Leeds, UK

3. Department of Women’s and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool Faculty of Health and Life Sciences , Liverpool, UK

4. Department of Paediatric Rheumatology, Alder Hey Children’s NHS Foundation Trust , Liverpool, UK

5. LUPUS UK , Romford, UK

6. Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust , Cambridge, UK

7. School of Health Sciences, University of Southampton , Southampton, UK

8. Musculoskeletal Research Unit, NIHR Southampton Clinical Research Facility, University Hospital Southampton , Southampton, UK

9. Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust , Harrow, UK

10. Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK

11. Department of Rheumatology, Freeman Hospital , Newcastle, UK

12. Centre for Rheumatology, Division of Medicine, University College London , London, UK

13. Department of Adolescent Rheumatology, St James’s Hospital and Children’s Health Ireland , Dublin, Ireland

14. Department of Rheumatology, St George’s University Hospitals NHS Foundation Trust , London, UK

15. Lifespan and Population Health, School of Medicine, University of Nottingham , Nottingham, UK

16. Nottingham University Hospitals NHS Trust , Nottingham, UK

17. Department of Dermatology, Leeds Teaching Hospitals NHS Trust , Leeds, UK

18. Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London , London, UK

19. Department of Paediatric Rheumatology, Manchester University NHS Foundation Trust , Manchester, UK

20. Centre for Musculoskeletal Health Research, School of Medicine, Keele University , Keele, UK

21. Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust , London, UK

22. NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health , London, UK

23. Department of Paediatric Rheumatology, Great Ormond Street Hospital NHS Foundation Trust , London, UK

24. Infection, Immunity and Inflammation Department, University College of London Great Ormond Street Institute of Child Health , London, UK

25. Pharmacy Department, Sheffield Children’s NHS Foundation Trust , Sheffield, UK

26. Department of Renal Medicine, Royal Free Hospital , London, UK

27. Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford, UK

28. Leeds Children’s Hospital, Leeds Teaching Hospitals NHS Trust , Leeds, UK

29. Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust , Bath, UK

30. Department of Clinical and Academic Rheumatology, King’s College Hospital NHS Foundation Trust , London, UK

31. Lanarkshire Centre for Rheumatology, Hairmyres Hospital , East Kilbride, Scotland, UK

Abstract

Abstract The objective of this guideline is to provide up-to-date, evidence-based recommendations for the management of SLE that builds upon the existing treatment guideline for adults living with SLE published in 2017. This will incorporate advances in the assessment, diagnosis, monitoring, non-pharmacological and pharmacological management of SLE. General approaches to management as well as organ-specific treatment, including lupus nephritis and cutaneous lupus, will be covered. This will be the first guideline in SLE using a whole life course approach from childhood through adolescence and adulthood. The guideline will be developed with people with SLE as an important target audience in addition to healthcare professionals. It will include guidance related to emerging approved therapies and account for National Institute for Health and Care Excellence Technology Appraisals, National Health Service England clinical commissioning policies and national guidance relevant to SLE. The guideline will be developed using the methods and rigorous processes outlined in ‘Creating Clinical Guidelines: Our Protocol’ by the British Society for Rheumatology.

Funder

British Society for Rheumatology

Publisher

Oxford University Press (OUP)

Subject

Rheumatology

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