Affiliation:
1. Centre for Research on Ageing, Health and Wellbeing
2. College of Engineering and Computer Science, The Australian National University, Canberra, Australia
Abstract
Abstract
Objectives
This study aimed to investigate the predictive value of cognitive/functional measures in combination with hippocampal volume (HCV) on the probability of conversion from mild cognitive impairment (MCI) to Alzheimer’s disease (AD).
Methods
The Rey Auditory Verbal Learning Test for immediate memory, Mini-Mental State Examination, a functional assessment for independent daily activities and Alzheimer’s Disease Assessment Scale were used as cognitive/functional measures and HCV as neuroimaging measure. Logistic regression and Cox proportional hazard analyses were used to explore the measures’ predictive values for AD conversion and time to conversion.
Results
The probability of conversion from MCI to AD was associated with cognitive function, but this was moderated by HCV: higher at lower HCV and lower at higher HCV. General cognitive/functional measures were less predictive than immediate memory in predicting time to conversion to AD at small HCVs.
Conclusion
Effectiveness of cognitive measures and subtle functional abnormality in predicting conversion from MCI to AD is dependent on HCV, thus combined evaluation should be considered. A combination of HCV and immediate memory appear to perform best in predicting time to conversion.
Funder
Alzheimer’s Disease Neuroimaging Initiative
National Institutes of Health
National Institute on Aging
National Institute of Biomedical Imaging and Bioengineering
Canadian Institutes of Health Research
Australian Commonwealth Government
Australian Government Research Training Program (RTP) Scholarship
Publisher
Oxford University Press (OUP)
Subject
Geriatrics and Gerontology,Gerontology,Clinical Psychology,Social Psychology
Cited by
17 articles.
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