Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial-Reference-Cited by-同舟云学术

Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants’ Nasopharynx: A Randomized Controlled Trial

Published:2020-05-23 Issue:12 Volume:71 Page:3222-3225
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Bojang Abdoulie¹,Baines Sarah L²,Camara Bully¹,Guerillot Romain²,Donovan Liam²,Marqués Raquel Sánchez¹,Secka Ousman¹,D’Alessandro Umberto¹,Bottomley Christian³,Howden Benjamin P²⁴,Roca Anna¹

Affiliation:

1. Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia

2. Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

3. Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, United Kingdom

4. Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

Abstract

Abstract In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. Clinical Trials Registration NCT1800942.

Funder

Medical Research Council

Department for International Development (DFID) under the MRC/DFID Concordat agreement

European Union

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa609/33785071/ciaa609.pdf

Reference18 articles.

1. Azithromycin to reduce childhood mortality in sub-Saharan Africa;Keenan;N Engl J Med,2018