Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms-Reference-Cited by-同舟云学术

Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms

Published:2020-07-18 Issue:8 Volume:72 Page:1444-1447
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Ghani Rohma¹²,Mullish Benjamin H¹³^ORCID,McDonald Julie A K¹⁴,Ghazy Anan²,Williams Horace R T¹³,Brannigan Eimear T²,Mookerjee Siddharth²,Satta Giovanni²,Gilchrist Mark²,Duncan Neill⁵,Corbett Richard⁵,Innes Andrew J⁶,Pavlů Jiří⁶,Thursz Mark R¹³,Davies Frances²,Marchesi Julian R¹⁷

Affiliation:

1. Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom

2. Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom

3. Department of Gastroenterology and Hepatology, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom

4. MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom

5. Department of Renal Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom

6. Centre for Haematology, Imperial College London, and Hammersmith Hospital, Imperial College London NHS Trust, London, United Kingdom

7. School of Biosciences, Cardiff University, Cardiff, United Kingdom

Abstract

Abstract Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.

Funder

National Institute for Health Research

Imperial Biomedical Research Centre

Medical Research Council

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa948/33644688/ciaa948.pdf

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