Coronavirus Disease 2019 (COVID-19) Transmission in the United States Before Versus After Relaxation of Statewide Social Distancing Measures

Author:

Tsai Alexander C123,Harling Guy45ORCID,Reynolds Zahra6,Gilbert Rebecca F6,Siedner Mark J1356

Affiliation:

1. Center for Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA

2. Health Policy Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA

3. Harvard Medical School, Boston, Massachusetts, USA

4. University College London, London, United Kingdom

5. Africa Health Research Institute, KwaZulu-Natal, South Africa

6. Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA

Abstract

Abstract Background Weeks after issuing social distancing orders to suppress severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and reduce growth in cases of severe coronavirus disease 2019 (COVID-19), all US states and the District of Columbia partially or fully relaxed these measures. Methods We identified all statewide social distancing measures that were implemented and/or relaxed in the United States between 10 March and 15 July 2020, triangulating data from state government and third-party sources. Using segmented linear regression, we estimated the extent to which relaxation of social distancing affected epidemic control, as indicated by the time-varying, state-specific effective reproduction number (Rt). Results In the 8 weeks prior to relaxation, mean Rt declined by 0.012 units per day (95% confidence interval [CI], −.013 to −.012), and 46/51 jurisdictions achieved Rt < 1.0 by the date of relaxation. After relaxation of social distancing, Rt reversed course and began increasing by 0.007 units per day (95% CI, .006–.007), reaching a mean Rt of 1.16. Eight weeks later, the mean Rt was 1.16 and only 9/51 jurisdictions were maintaining an Rt < 1.0. Parallel models showed similar reversals in the growth of COVID-19 cases and deaths. Indicators often used to motivate relaxation at the time of relaxation (eg, test positivity rate <5%) predicted greater postrelaxation epidemic growth. Conclusions We detected an immediate and significant reversal in SARS-CoV-2 epidemic suppression after relaxation of social distancing measures across the United States. Premature relaxation of social distancing measures undermined the country’s ability to control the disease burden associated with COVID-19.

Funder

National Institutes of Health

Sullivan Family Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference51 articles.

1. An interactive web-based dashboard to track COVID-19 in real time;Dong;Lancet Infect Dis,2020

2. Systemic racism, chronic health inequities, and COVID-19: a syndemic in the making?;Gravlee;Am J Hum Biol,2020

3. US elections: treating the acute-on-chronic decompensation;Tsai;Lancet Public Health 2020; 5:E519–20

4. The effect of large-scale anti-contagion policies on the COVID-19 pandemic;Hsiang;Nature,2020

5. Social distancing to slow the US COVID-19 epidemic: longitudinal pretest-posttest comparison group study;Siedner;PLoS Med,2020

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3