Devastating Gynecological Infections in Women with STAT3 Deficiency

Author:

Redor Alexis1,Danion François1,Parize Perrine1,Chandesris Olivia1,Dbjay Jonathan1,Duréault Amélie1,Le Guenno Guillaume2,Cazorla Celine3,Vergnon-Miszczycha Delphine3,Bats Anne Sophie4,Bodemer Christine5,Hoarau Cyrille6,Charlier Caroline178,Mahlaoui Nizar179,Lecuit Marc1710,Lanternier Fanny178,Lortholary Olivier178

Affiliation:

1. Paris University, Necker-Pasteur Center for Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, University Hospital Institute (IHU)  Imagine, Paris, France

2. Department of Internal Medicine, University Estaing Hospital, Clermont Ferrand, France

3. Department of Infectious Diseases and Tropical Medicine, University Hospital, Saint Etienne, France

4. Paris University, Department of Gynecologic Surgery, Georges Pompidou University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

5. Paris University, Department of Dermatology, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, IHU Imagine, Paris, France

6. Department of Immunology, University Hospital, Tours, France

7. French National Reference Center for Primary Immune Deficiencies, Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

8. Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, Paris, France

9. Pediatric Immuno-Hematology and Rheumatology Unit, Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

10. Institut Pasteur, Biology of Infection Unit, Inserm, Paris, France

Abstract

Abstract We provide the first description of a series of 9 severe gynecological infections (mastitis and pelvic cellulitis) occurring in the French national cohort of women with STAT3 deficiency. Each episode had unique features in terms of clinical presentation, microbial documentation, location, treatment duration, and related persistent esthetic damage.

Funder

French Ministry of Health

CSL Behring, Shire, Octapharma, Grifols, and Binding Site

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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