Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid-Reference-Cited by-同舟云学术

Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid

Published:2020-07-30 Issue:12 Volume:73 Page:2329-2331
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Yoshiyama Takashi¹²^ORCID,Takaki Akiko³,Aono Akio³,Mitarai Satoshi³,Okumura Masao²,Ohta Ken⁴,Kato Seiya¹

Affiliation:

1. Research Institute of Tuberculosis, Tokyo, Japan

2. Respiratory Diseases Center, Fukujuji Hospital, Tokyo, Japan

3. Department of Mycobacterium Reference and Research, Research institute of tuberculosis, Tokyo, Japan

4. Fukujuji Hospital, Tokyo, Japan

Abstract

Abstract This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate. The minimum inhibitory concentrations for BDQ and DLM were 0.25 µg/mL and >2.0 µg/mL, respectively.

Funder

Japan Agency for Medical Research and Development

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa1064/41276315/ciaa1064.pdf

Reference10 articles.

1. Acquired resistance to bedaquiline and delamanid in therapy for tuberculosis;Bloemberg;N Engl J Med,2015

2. Emergence of low-level delamanid and bedaquiline resistance during extremely drug-resistant tuberculosis treatment;Polsfuss;Clin Infect Dis,2019

3. How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis;Mitchison;Int J Tuberc Lung Dis,1998

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design and synthesis of Thieno[3, 2-b]pyridinone derivatives exhibiting potent activities against Mycobacterium tuberculosis in vivo by targeting Enoyl-ACP reductase;European Journal of Medicinal Chemistry;2024-12

2. Degarelix Limits the Survival of Mycobacteria and Granuloma Formation;2024

3. Antituberculars;Reactions Weekly;2023-07-01

4. Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB;Emerging Infectious Diseases;2023-05

5. L-Tyrosine Limits Mycobacterial Survival in Tuberculous Granuloma;Pathogens;2023-04-28