Age-Specific Incidence of Influenza A Responds to Change in Virus Subtype Dominance

Author:

Gagnon Alain12,Acosta Enrique13,Miller Matthew S4

Affiliation:

1. Département de démographie, Université de Montréal, Montreal, Canada

2. Centre de recherche en santé publique, Montreal, Canada

3. Max Planck Institute for Demographic Research, Rostock, Germany

4. Department of Biochemistry and Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Canada

Abstract

Abstract When H3N2 replaced H1N1 as the dominant influenza A subtype during the 2018–2019 season, the pattern of age-specific incidence shifted due to the lingering effects of antigenic imprinting. The characteristic shape that imprinting leaves on influenza susceptibility could foster important advances in understanding and predicting the epidemiology of influenza.

Funder

Canadian Institutes of Health Research

Social Sciences and Humanities Research Council of Canada

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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