Management of Drug Toxicity in Mycobacterium avium Complex Pulmonary Disease: An Expert Panel Survey

Author:

van Ingen Jakko1ORCID,Aliberti Stefano23,Andrejak Claire4,Chalmers James D5,Codecasa Luigi R6,Daley Charles L7,Hasegawa Naoki8,Griffith David E9,Hoefsloot Wouter10,Huitt Gwen7,Jarand Julie11,Jhun Byung Woo12,Loebinger Michael R1314,Marras Theodore K15,Morimoto Kozo16,Polverino Eva17,Ringshausen Felix C18,Santin Miguel19,Thomson Rachel20,Wagner Dirk21,Wallace Richard J22,Winthrop Kevin L23,Yim Jae-Joon24

Affiliation:

1. Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands

2. University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy

3. Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy

4. Department of Pneumology, University Hospital of Amiens-Picardie, Amiens, France

5. Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom

6. Regional Tuberculosis Reference Centre, Villa Marelli Institute-Niguarda Hospital, Milan, Italy

7. Division of Mycobacterial and Respiratory Infections, National Jewish Health and University of Colorado, Denver, Colorado, USA

8. Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan

9. Department of Medicine, University of Texas Health Science Center at Tyler, Tyler, Texas, USA

10. Center for Infectious Diseases, Department of Pulmonology, Radboud University Medical Center, Nijmegen, The Netherlands

11. Division of Respiratory Medicine, Department of Medicine, University of Calgary, Calgary, Canada

12. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

13. Host Defence Unit, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom

14. National Heart and Lung Institute, Imperial College, London, United Kingdom

15. Departments of Medicine at the Toronto Western Hospital/University Health Network and the University of Toronto, Toronto, Canada

16. Respiratory Disease Center, Fukujuji Hospital, Anti-Tuberculosis Association, Tokyo, Japan

17. Servei de Pneumologia, Hospital Universitari Vall d’Hebron, Institut de Recerca Vall d’Hebron, Barcelona, Spain

18. Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in Endstage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hannover, Germany

19. Service of Infectious Diseases, Bellvitge University Hospital, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain

20. Gallipoli Medical Research Institute, University of Queensland, Brisbane, Australia

21. Division of Infectious Diseases, Department of Medicine II, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

22. Mycobacteria/Nocardia Research Laboratory, University of Texas Health Science Center at Tyler, Tyler, Texas, USA

23. Oregon Health and Science University, Portland, Oregon, USA

24. Division of Pulmonary and Critical Care Medicine, Seoul National University College of Medicine, Seoul, South Korea

Abstract

Abstract Adverse events are frequent in nontuberculous mycobacteria pulmonary disease treatment, but evidence to support their management is scarce. An expert panel survey on management of adverse events shows consistent opinions on management of hepatoxicity, ocular toxicity, ototoxicity, tinnitus, and gastrointestinal upset. These opinions can provide assistance in individual patient management decisions.

Funder

Physicians World Europe GmbH

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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