Multi-inflammatory Syndrome in Children Related to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Spain

Author:

Moraleda Cinta12,Serna-Pascual Miquel2,Soriano-Arandes Antoni3,Simó Silvia4,Epalza Cristina1,Santos Mar5,Grasa Carlos6,Rodríguez Maria7,Soto Beatriz8,Gallego Nerea9,Ruiz Yolanda10,Urretavizcaya-Martínez María11,Pareja Marta12,Sanz-Santaeufemia Francisco José13,Fumadó Victoria4,Lanaspa Miguel4,Jordan Iolanda14,Prieto Luis1,Belda Sylvia15,Toral-Vázquez Belén16,Rincón Elena5,Gil-Villanueva Nuria17,Méndez-Echevarría Ana6,Castillo-Serrano Ana12,Rivière Jacques G3,Soler-Palacín Pere3,Rojo Pablo12,Tagarro Alfredo218ORCID,del Valle Rut,Barrios Ana,Villanueva Sara,Contreras Jesús R,Gutiérrez Lourdes,Calvo Cristina,Molino Paula R,José Mellado María,de Ceano María,Penin María,Villaverde Serena,José Pérez María,Otheo Enrique,Dolores Falcón María,Neth Olaf,Olbrich Peter,Goycoechea Walter,Martín Laura,Isabel Iglesias María,Antonio Alonso Cadenas José,Herrero Blanca,Cobo Elvira,Tovizi Mariam,Galán Pilar,Guillén Sara,Navas Adriana,Luz García-García M,Llorente Marta,Pérez Sara,Figueroa Lucía,Bermejo Amanda,Mendoza Pablo,Sabrido Gema,José Hernández María,Belén Jiménez Ana,Berzosa Arantxa,Illán Marta,Bernardino María,Jensen Julia,Vidal Paula,Domínguez Sara,Gutiérrez Lourdes,Ocaña Angustias,Romero Isabel,Fernanda Guzmán María,Pascual M J,López Machín Ana,Ruiz Beatriz,Menasalvas Ana,Méndez María,Hurtado Ángela,Ara Fátima,Cabañas Fernando,Oltra Manuel,Villarroya Álvaro,Sánchez-Códez María,Montesinos Elena,Herranz Aguirre Mercedes,Rius Neus,Gómez Alba,Bretón Rafael,Rodríguez-Benjumea Margarita,Campos Ana,García Reymundo Mercedes,

Affiliation:

1. Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain

2. Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (IMAS12); Fundación para la Investigación Biomédica del Hospital 12 de Octubre, Madrid, Spain, RITIP (Traslational Research Network in Pediatric Infectious Diseases)

3. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Barcelona, Spain

4. Infectious and Imported Diseases Unit, Department of Pediatrics, Sant Joan de Déu Universitary Hospital Research Foundation, Barcelona, Spain

5. Pediatric Infectious Diseases Unit, Hospital Universitario Gregorio Marañón, Madrid, Spain

6. Pediatrics and Infectious Disease Unit, Pediatrics Department, Hospital Universitario La Paz. Fundación IdiPaz, Madrid, Spain, Red de Investigación Traslacional en Infectología Pediátrica (RITIP)

7. Pediatrics Department. Hospital Universitario Infanta Cristina, Parla, Madrid, Spain

8. Pediatrics Department, Hospital Universitario de Getafe, Getafe, Madrid, Spain

9. Pediatrics Department, Hospital Universitario Son Espases. Palma de Mallorca, Illes Baleares, Spain

10. Pediatrics Department, Hospital Universitario San Pedro, Logroño, La Rioja, Spain

11. Pediatrics Department, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain

12. Complejo Hospitalario Universitario de Albacete, Albacete, Castilla-La Mancha, Spain

13. Pediatrics Department. Hospital Universitario Niño Jesús, Madrid, Spain

14. Pediatric Intensive Care Unit, Sant Joan de Deu Universitary Hospital, CIBERES, Barcelona, Spain

15. Pediatric Intensive Care Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, School of Medicine, Complutense University of Madrid, Mother-Child Health and Development Network (Red SAMID) of Carlos III Health Institute, Madrid, Spain

16. Pediatric Cardiology Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain

17. Department of Paediatric Cardiology, H.G.U. Gregorio Marañón, Madrid, Spain

18. Pediatrics Department, Hospital Universitario Infanta Sofía, Pediatrics Research Group, Universidad Europea de Madrid, Madrid, Spain

Abstract

Abstract Some clusters of children with a multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. We describe the epidemiological and clinical features of children with MIS-C in Spain. MIS-C is a potentially severe condition that presents in children with recent SARS-CoV-2 infection.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference5 articles.

1. Hyperinflammatory shock in children during COVID-19 pandemic;Riphagen;Lancet,2020

2. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study;Verdoni;Lancet,2020

3. An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations;Cheng;bioRxiv,2020

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