Two fatal cases of acute liver failure due to HSV-1 infection in COVID-19 patients following immunomodulatory therapies

Author:

Busani Stefano1,Bedini Andrea2,Biagioni Emanuela1,Serio Lucia1,Tonelli Roberto3,Meschiari Marianna2,Franceschini Erica2,Guaraldi Giovanni2ORCID,Cossarizza Andrea4,Clini Enrico3,Maiorana Antonino5,Gennari William6,De Maria Nicola7,Luppi Mario8,Mussini Cristina2,Girardis Massimo1,

Affiliation:

1. Anesthesia and Intensive Care Medicine, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy

2. Infectious Diseases Unit, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy

3. Respiratory Diseases Unit, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy

4. Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

5. Institute of General Pathology, University of Modena and Reggio Emilia, Modena, Italy

6. Virology and Molecular Microbiology Unit, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy

7. Gastroenterology Unit, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy

8. Hematology Unit, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy

Abstract

Abstract We reported two fatal cases of acute liver failure secondary to Herpes Simplex Virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy.Screening for and prompt recognition of Herpes Simplex Virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentiallyrelevant clinical consequences.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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