Severe Acute Respiratory Syndrome Coronavirus 2 RNA in Plasma Is Associated With Intensive Care Unit Admission and Mortality in Patients Hospitalized With Coronavirus Disease 2019

Author:

Prebensen Christian12ORCID,Myhre Peder L23,Jonassen Christine4,Rangberg Anbjørg4,Blomfeldt Anita5,Svensson My6,Omland Torbjørn23,Berdal Jan-Erik12

Affiliation:

1. Department of Infectious Diseases, Division of Medicine, Akershus University Hospital, Lørenskog, Norway

2. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

3. Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway

4. Center for Laboratory Medicine, Østfold Hospital Trust, Grålum, Norway

5. Department of Microbiology and Infection Control, Division for Diagnostics and Technology, Akershus University Hospital, Lørenskog, Norway

6. Department of Research, Division of Medicine, Akershus University Hospital, Lørenskog, Norway

Abstract

Abstract The clinical significance of severe acute respiratory syndrome coronavirus 2 RNA in the circulation is unknown. In this prospective cohort study, we detected viral RNA in the plasma of 58 of 123 (47%) patients hospitalized with coronavirus disease 2019. RNA was detected more frequently, and levels were higher, in patients who were admitted to the intensive care unit and/or died.

Funder

Universitetet i Oslo

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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