Severe Acute Respiratory Syndrome Coronavirus 2 Spreads to Lymph Nodes and Strongly Expands CD4+ Effector Memory RA Cells in a Patient With Mild Coronavirus Disease 2019-Reference-Cited by-同舟云学术

Severe Acute Respiratory Syndrome Coronavirus 2 Spreads to Lymph Nodes and Strongly Expands CD4+ Effector Memory RA Cells in a Patient With Mild Coronavirus Disease 2019

Published:2020-09-18 Issue:11 Volume:73 Page:e3970-e3973
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Roldán-Santiago Ernesto¹,Benito-Berlinches Amparo²,Martínez-García Laura³,Quereda Carmen⁴,Rodríguez-Martín Eulalia¹,Pérez-Elías Pilar⁵,López-Pintor Jose María³,Walo-Delgado Paulette Esperanza¹,Moreno-Zamora Ana⁴,Fernández-Velasco Jose Ignacio¹,García-Abellás Patricia²,Ballester-González Rubén¹,Villar Luisa M¹,Pérez-Elías María Jesús⁴^ORCID

Affiliation:

1. Immunology, Hospital Ramón y Cajal Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain

2. Pathology, Hospital Ramón y Cajal IRYCIS, Madrid, Spain

3. Microbiology, Hospital Ramón y Cajal IRYCIS, Madrid, Spain

4. Infectious Diseases, Hospital Ramón y Cajal IRYCIS, Madrid, Spain

5. Primary Care, Centro de Salud García Noblejas, Madrid, Spain

Abstract

Abstract A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+ T cells, a cell population that is practically absent in lymph nodes.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa1422/34032212/ciaa1422.pdf

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