Coronavirus Disease 2019 (COVID-19) Seropositivity and Asymptomatic Rates in Healthcare Workers Are Associated with Job Function and Masking

Author:

Sims Matthew D123,Maine Gabriel N45,Childers Karen Lins6,Podolsky Robert H6,Voss Daniel R7,Berkiw-Scenna Natalie8,Oh Joyce9,Heinrich Kevin E10,Keil Hans9,Kennedy Richard H113,Homayouni Ramin3

Affiliation:

1. Section of Infectious Diseases and International Medicine, Department of Internal Medicine, Beaumont Royal Oak, Royal Oak, MI, USA

2. Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA

3. Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, USA

4. Pathology and Laboratory Medicine, Beaumont Royal Oak, Royal Oak, MI, USA

5. Department of Pathology, Oakland University William Beaumont School of Medicine, Rochester, MI, USA

6. Biostatistics, Beaumont Research Institute, Royal Oak, MI, USA

7. Research Computing, Beaumont Research Institute, Royal Oak, MI, USA

8. Project Management Office, Beaumont Health, Southfield, MI, USA

9. Information Technology, Beaumont Health, Southfield, MI, USA

10. Quire Inc., Memphis, TN, USA

11. Beaumont Research Institute, Royal Oak, MI, USA

Abstract

Abstract Background Although the risk of exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is higher for frontline healthcare workers, not all personnel have similar risks. Determining infection rate is difficult due to the limits on testing and the high rate of asymptomatic individuals. Detection of antibodies against SARS-CoV-2 may be useful for determining prior exposure to the virus and assessing mitigation strategies, such as isolation, masks, and other protective equipment. Methods An online assessment that included demographic, clinical, and exposure information and a blood sample was collected from 20 614 participants out of ~43 000 total employees at Beaumont Health, which includes 8 hospitals distributed across the Detroit metropolitan area in southeast Michigan. The presence of anti-SARS-CoV-2 IgG was determined using the EUROIMMUN assay. Results A total of 1818 (8.8%) participants were seropositive between April 13 and May 28, 2020. Among the seropositive individuals, 44% reported that they were asymptomatic during the month prior to blood collection. Healthcare roles such as phlebotomy, respiratory therapy, and nursing/nursing support exhibited significantly higher seropositivity. Among participants reporting direct exposure to a Coronavirus Disease 2019 (COVID-19) positive individual, those wearing an N95/PAPR mask had a significantly lower seropositivity rate (10.2%) compared to surgical/other masks (13.1%) or no mask (17.5%). Conclusions Direct contact with COVID-19 patients increased the likelihood of seropositivity among employees but study participants who wore a mask during COVID-19 exposures were less likely to be seropositive. Additionally, a large proportion of seropositive employees self-reported as asymptomatic. (Funded by Beaumont Health and by major donors through the Beaumont Health Foundation) ClinicalTrials.gov number NCT04349202

Funder

Beaumont Health Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference30 articles.

1. Coronavirus Disease 2019 (COVID-2019) infection among health care workers and implications for prevention measures in a tertiary hospital in Wuhan, China;Lai;JAMA Netw Open,2020

2. Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial;Li;JAMA,2020

3. Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study;Nguyen;Lancet Public Heal,2020

4. Serum IgA, IgM, and IgG responses in COVID-19;Ma;Cell Mol Immunol,2020

5. Seroprevalence of antibodies to SARS-CoV-2 in 10 sites in the United States, March 23-May 12, 2020. [manuscript published online ahead of print 21 July 2020];Havers;JAMA Intern Med,2020

Cited by 59 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3