A Conceptual Discussion About the Basic Reproduction Number of Severe Acute Respiratory Syndrome Coronavirus 2 in Healthcare Settings

Author:

Temime Laura12,Gustin Marie-Paule34,Duval Audrey56,Buetti Niccolò7,Crépey Pascal5,Guillemot Didier568,Thiébaut Rodolphe91011,Vanhems Philippe41213,Zahar Jean-Ralph1415,Smith David R M156,Opatowski Lulla56

Affiliation:

1. MESuRS laboratory, Conservatoire national des arts et métiers, Paris, France

2. PACRI Unit, Institut Pasteur, Conservatoire national des arts et métiers, Paris, France

3. Institute of Pharmaceutic and Biological Sciences, University Claude Bernard Lyon 1, Villeurbanne, France

4. Emerging Pathogens Laboratory-Fondation Mérieux, International Center for Infectiology Research (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon, France

5. Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, CESP, Anti-infective evasion and pharmacoepidemiology team, Montigny-Le-Bretonneux, France

6. Institut Pasteur, Epidemiology and Modelling of Antibiotic Evasion unit, Paris, France

7. UPRES-EA 7449 REPERES “Recherche en Pharmaco-Epidémiologie et Recours aux Soins” – EHESP – Université de Rennes, Rennes, France

8. AP-HP Paris Saclay, Public Health, Medical Information, Clinical research, Le Kremlin-Bicêtre, France

9. INSERM U1219 Bordeaux Population Health, Université de Bordeaux, Bordeaux, France

10. INRIA SISTM team, Talence, France

11. Vaccine Research Institute, Créteil, France

12. Service d’Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, F-69437, Lyon, France

13. Inserm, F CRIN, Réseau Innovative Clinical Research in Vaccinology (I-REIVAC), Paris, France

14. IAME, UMR1137, Inserm, Univ. Paris 13, Sorbonne Paris Cité, Paris, France

15. Service de Microbiologie Clinique et Unité de Contrôle et de Prévention du Risque Infectieux, Groupe Hospitalier Paris Seine Saint-Denis, AP-HP, Bobigny, France

Abstract

Abstract To date, no specific estimate of R0 for SARS-CoV-2 is available for healthcare settings. Using interindividual contact data, we highlight that R0 estimates from the community cannot translate directly to healthcare settings, with pre-pandemic R0 values ranging 1.3–7.7 in 3 illustrative healthcare institutions. This has implications for nosocomial COVID-19 control.

Funder

National Research Agency project SPHINX

Canadian Institutes for Health Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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