Hydroxychloroquine in Coronavirus Disease 2019 Patients: What Still Needs to Be Known About the Kinetics-Reference-Cited by-同舟云学术

Hydroxychloroquine in Coronavirus Disease 2019 Patients: What Still Needs to Be Known About the Kinetics

Published:2020-05-11 Issue:11 Volume:71 Page:2962-2964
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Martin-Blondel Guillaume¹,Ruiz Stéphanie²,Murris Marlène³,Faguer Stanilas⁴,Duhalde Véronigue⁵,Eyvrard Frédéric⁵,Izopet Jacques⁶,Mansuy Jean-Michel⁶,Rolland Yves⁷,Delavigne Karen⁸,Guimbaud Rosine⁹,Pugnet Grégory¹⁰,Conil Jean-Marie²,Georges Bernard²,Delobel Pierre¹,Minville Vincent²,Silva Sifontes Stein¹¹,Concordet Didier¹²,Gandia Peggy¹²¹³

Affiliation:

1. Service des Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

2. Service de Réanimation - Rangueil, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

3. Service de Pneumologie - CRCM, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

4. Pôle de Néphrologie et Transplantation d’Organes, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

5. Pôle Pharmacie, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

6. Laboratoire de Virologie, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

7. Pôle de Gériatrie, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

8. Service d’Hématologie, IUCT-Oncopole, Toulouse, France

9. Pôle des Maladies de l’Appareil Digestif, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

10. Service de Médecine Interne, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

11. Service de Réanimation - Purpan, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

12. UMR INTHERES, INRA-ENVT, Toulouse, France

13. Laboratoire de Pharmacocinétique et Toxicologie, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France

Abstract

Abstract Different dosage regimens of hydroxychloroquine are used to manage coronavirus disease 2019 (COVID-19) patients, without information on the pharmacokinetics in this population. Blood samples (n = 101) were collected from 57 COVID-19 patients for 7 days, and concentrations were compared with simulated kinetic profiles. Hydroxychloroquine exposure is low and cannot be predicted by other populations.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa558/33524161/ciaa558.pdf

Reference13 articles.

1. No evidence of rapid;Molina;Médecine et Maladies Infectieuses,2020

2. Hydroxychloroquine and azithromycin;Gautret;Int J Antimicrob Agents,2020

3. A pilot study;Chen;J Zhejiang University (Medical Science),2020

4. Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases;Rainsford;Inflammopharmacology,2015

5. Steady-state pharmacokinetics of hydroxychloroquine in patients with cutaneous lupus erythematosus;Al-Rawi;Lupus,2018

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