High Prevalence and High Rate of Antibiotic Resistance of Mycoplasma genitalium Infections in Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Pre-exposure Prophylaxis Trial

Author:

Berçot Béatrice12,Charreau Isabelle3,Rousseau Clotilde2,Delaugerre Constance45,Chidiac Christian6,Pialoux Gilles7,Capitant Catherine3,Bourgeois-Nicolaos Nadège8,Raffi François910,Pereyre Sabine1112,Le Roy Chloé1112,Senneville Eric13,Meyer Laurence314,Bébéar Cécile1112,Molina Jean-Michel415,Pintado C,Loze B,Gatey C,Ponscarme D,Penot P,Veron R,Delgado J,Dalle E,Parlier S,Madelaine I,Danet M,Mahjoub N,Mezreb N,Moudachirou K,Morel S,Conort G,Lorho F,Meunier M,Rozenbaum W,Monfort C,Foucoin J,Boissavy B,Cousseau S,Huon S,Danet M,Djessima A,Berrebi V,Adda A,le Nagat S,Zarka L,Berdougo J,Mzoughi N,Clement F,Decouty A,Chapolard C,Godinot M,Adouard-Groslafeige C,Koffi J,Pansu A,Becker A,Pailhes S,Bonnet F,Jeanblanc F,Brochier C,Teruin X,Rouby S,Gilly L,Etienne C,Tolonin F,Breaud S,Péchenot V,Bagge S,Cepitelli T,Roger P M,Rosenthal E,Cheret A,Cornavin P,Vandamme S,Lambec J,Dumon N,Leclanche O,Huleux T,Biekre R,Melliez H,Bazus H,Pasquet A,Bernaud C,Besnier M,Bonnet B,Hall N,Cavellec M,Hue H,Larmet L,Colas M,Choquet R,Fouéré S,Netzer E,Leturque N,Binesse J,Foubert V,Saouzanet M,Euphrasie F,Guillon B,Saïdi Y,Suzan M,Cattin G,Demoulin B,Lorente N,

Affiliation:

1. Infection Antimicrobials Modelling Evolution (IAME), INSERM UMR1137, Paris University, Paris, France

2. Associated Laboratory of the French National Center for Bacterial Sexually Transmitted Infections, Bacteriology Unit, Saint-Louis Hospital, AP-HP, Paris, France

3. INSERM SC10-US19, Villejuif, France

4. INSERM UMR 941, Paris University, France

5. Virology Unit, Saint-Louis Hospital, APHP, Paris, France

6. Department of Infectious Diseases, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France

7. Department of Infectious Diseases, Hôpital Tenon, Paris, France

8. Department of Microbiology, Antoine Béclère Hospital, APHP, Clamart, France

9. Department of Infectious Diseases, CHU Nantes, Nantes, France

10. CIC 1413, INSERM, Nantes, France

11. Bacteriology Department, French National Center for Bacterial Sexually Transmitted Infections, CHU Bordeaux, Bordeaux, France

12. USC EA 3671, University of Bordeaux, Bordeaux, France

13. Infectious Diseases Department, Gustave Dron Hospital, Tourcoing, France

14. Paris Sud University, Paris Saclay, France

15. Department of Infectious Diseases, Saint-Louis and Lariboisière Hospitals, APHP, Paris, France

Abstract

Abstract Background Mycoplasma genitalium (MG) is an emerging pathogen among men who have sex with men (MSM) with raising rates of antibiotic resistance. This study assessed the prevalence and incidence of MG infection in MSM enrolled in the open-label phase of the ANRS IPERGAY trial with on-demand tenofovir disoproxil fumarate/emtricitabine for human immunodeficiency virus prevention and the impact of doxycycline post-exposure prophylaxis (PEP). Methods 210 subjects were tested at baseline and at 6 months by real-time PCR assays for MG detection in urine samples and oropharyngeal and anal swabs. Resistance to azithromycin (AZM), to fluoroquinolones (FQs), and to doxycycline was investigated in the French National Reference Center of Bacterial Sexually Transmitted Infections (STIs). Results The all-site prevalence of MG at baseline was 10.5% (6.3% in urine samples, 4.3% in anal swabs, 0.5% in throat swabs) and remained unchanged at 6 months whether or not PEP was used: 9.9% overall, 10.2% with PEP, 9.6% without. The overall rate of MG resistance (prevalent and incident cases) to AZM and FQs was 67.6% and 9.1%, respectively, with no difference between arms. An in vivo mutation of the MG 16S rRNA, which could be associated with tetracycline resistance, was observed in 12.5% of specimens tested. Conclusions The prevalence of MG infection among MSM on pre-exposure prophylaxis was high and its incidence was not decreased by doxycycline prophylaxis with a similar high rate of AZM and FQ resistance, raising challenging issues for the treatment of this STI and supporting current recommendations to avoid testing or treatment of asymptomatic MG infection.

Funder

ANRS

Fonds de Dotation Pierre Bergé pour la Prévention—SIDACTION

Bill and Melinda Gates Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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