Sustained Response After Remdesivir and Convalescent Plasma Therapy in a B-Cell–Depleted Patient With Protracted Coronavirus Disease 2019 (COVID-19)-Reference-Cited by-同舟云学术

Sustained Response After Remdesivir and Convalescent Plasma Therapy in a B-Cell–Depleted Patient With Protracted Coronavirus Disease 2019 (COVID-19)

Published:2020-10-26 Issue:11 Volume:73 Page:e4020-e4024
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Malsy Jakob¹,Veletzky Luzia¹,Heide Janna¹²,Hennigs Annette¹,Gil-Ibanez Ines¹,Stein Alexander³⁴,Lütgehetmann Marc²⁵,Rosien Ulrich⁶,Jasper Dorothea⁶,Peine Sven⁷,Hiller Jens⁷,Haag Friedrich⁸,Schmiedel Stefan¹,Huber Samuel¹,Jordan Sabine¹,Addo Marylyn M¹²,Schulze zur Wiesch Julian¹²

Affiliation:

1. Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

2. German Center for Infection Research (DZIF), Hamburg-Lubeck-Borstel-Riems, Germany

3. Hämatologisch-Onkologische Praxis Eppendorf (HOPE), Hamburg, Germany

4. University Cancer Center Hamburg (UCCH), Hamburg, Germany

5. Institute of Medical Microbiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

6. Department of Medicine, Israelitisches Krankenhaus, Hamburg, Germany

7. Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

8. Department of Clinical Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Abstract

Abstract We provide detailed clinical, virological, and immunological data of a B-cell–depleted patient treated with obinutuzumab for follicular lymphoma with protracted coronavirus disease 2019 (COVID-19) and viremia. A sustained response was achieved after 2 courses of remdesivir and subsequent convalescent plasma therapy. Immunocompromised patients might require combined and prolonged antiviral treatment regimens.

Funder

Deutsche Forschungsgemeinschaft

German Center for Infection

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa1637/36250514/ciaa1637.pdf

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