Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Upper Respiratory Tract of Children and Adults With Early Acute Coronavirus Disease 2019 (COVID-19)

Author:

Baggio Stéphanie12,L’Huillier Arnaud G34,Yerly Sabine4,Bellon Mathilde4,Wagner Noémie3,Rohr Marie3,Huttner Angela5,Blanchard-Rohner Géraldine36,Loevy Natasha7,Kaiser Laurent458,Jacquerioz Frédérique5910,Eckerle Isabella45811

Affiliation:

1. Division of Prison Health, Geneva University Hospitals, Geneva, Switzerland

2. Office of Corrections, Department of Justice and Home Affairs of the Canton of Zurich, Zurich, Switzerland

3. Children’s Hospital of Geneva, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

4. Laboratory of Virology, Division of Laboratory Medicine, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

5. Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

6. Center for Vaccinology and Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland

7. Pediatric Platform for Clinical Research, Department of Woman, Child and Adolescent Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland

8. Center for Emerging Viral Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

9. Division of Tropical and Humanitarian Medicine, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

10. Primary Care Division, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

11. Department of Molecular Medicine and Microbiology, Faculty of Medicine, Université de Genève, Geneva, Switzerland

Abstract

Abstract The factors that contribute to transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by children are unclear. We analyzed viral load at the time of diagnosis in 53 children and 352 adults with coronavirus disease 2019 (COVID-19) in the first 5 days post symptom onset. No significant differences in SARS-CoV-2 RNA loads were seen between children and adults.

Funder

Swiss National Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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