Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) With a History of Coinfection With Human Immunodeficiency Virus Type 1 and Hepatitis C Virus

Author:

Zhao Juanjuan1,Liao Xuejiao1,Wang Haiyan1,Wei Lanlan1,Xing Mingzhao2,Liu Lei12,Zhang Zheng12ORCID

Affiliation:

1. Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen, Guangdong, China

2. School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China

Abstract

Abstract The effect of host immune status on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Here, we report the first case of coronavirus disease 2019 (COVID-19) with human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus coinfection, who showed a persistently negative SARS-CoV-2 RNA test but delayed antibody response in the plasma. This case highlights the influence of HIV-1–induced immune dysfunction on early SARS-CoV-2 clearance.

Funder

Shenzhen Science and Technology Research and Development Project

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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