Occurrence and Timing of Subsequent Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-transcription Polymerase Chain Reaction Positivity Among Initially Negative Patients

Author:

Long Dustin R1ORCID,Gombar Saurabh2,Hogan Catherine A23,Greninger Alexander L45,O’Reilly-Shah Vikas6,Bryson-Cahn Chloe7,Stevens Bryan23,Rustagi Arjun8,Jerome Keith R45,Kong Christina S2,Zehnder James2,Shah Nigam H9,Weiss Noel S10,Pinsky Benjamin A238,Sunshine Jacob E6

Affiliation:

1. Division of Critical Care Medicine, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, Washington, USA

2. Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

3. Clinical Virology Laboratory, Stanford Health Care, Stanford, California, USA

4. Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA

5. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

6. Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, Washington, USA

7. Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, Washington, USA

8. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA

9. Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA

10. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA

Abstract

Abstract Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction test discordance among individuals initially testing negative by nasopharyngeal swab who were retested on clinical grounds within 7 days. The frequency of subsequent positivity within this window was 3.5% and was similar across institutions.

Funder

National Institute of General Medical Sciences

National Institute on Drug Abuse

National Institutes of Health

National Science Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference10 articles.

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2. Detection of SARS-CoV-2 in different types of clinical specimens;Wang;JAMA,2020

3. Sensitivity of chest CT for COVID-19: comparison to RT-PCR [published online ahead of print 19 February 2020];Fang;Radiology,2020

4. First case of 2019 novel coronavirus in the United States;Holshue;N Engl J Med,2020

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