Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira-Reference-Cited by-同舟云学术

Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira

Published:2020-01-29 Issue:8 Volume:71 Page:1990-1993
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Crainey James Lee¹^ORCID,Costa Carlos Henrique Aguiar¹²,de Oliveira Leles Lorena Ferreira¹³,Ribeiro da Silva Túllio Romão¹⁴,de Aquino Narzetti Luiz Henrique¹,Serra dos Santos Yago Vinícius¹³,Costa Conteville Liliane²⁵,Costa Pessoa Felipe Arley¹,Carvajal Cortés José Joaquin¹,Vicente Ana Carolina Paulo⁵,Rubio Muñoz José Miguel⁵,Bessa Luz Sérgio Luiz¹

Affiliation:

1. Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz Amazônia, Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Manaus, Brazil

2. Programa de Pós-graduação Stricto Sensu em Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

3. Programa de Pós-Graduação Stricto Sensu em Biologia da Interação Patógeno Hospedeiro, Manaus, Brazil

4. Programa de Pós-graduação Stricto Sensu em Biologia Parasitária, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

5. Malaria & Emerging Parasitic Diseases Laboratory, National Microbiology Center, Instituto de Salud Carlos III, Madrid, Spain

Abstract

Abstract Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our results confirm mansonellosis coinfections and have important implications for the disease’s treatment and diagnosis.

Funder

Fundação de Amparo à Pesquisa do Estado do Amazonas

Brazilian National Council for Scientific and Technological Development

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa082/33211088/ciaa082.pdf

Reference13 articles.

1. Mansonellosis: current perspectives;Ta-Tang;Res Rep Trop Med,2018

2. Molecular verification of new world Mansonella perstans parasitemias;Tavares da Silva;Emerg Infect Dis,2017