An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019-Reference-Cited by-同舟云学术

An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019

Published:2020-05-14 Issue:16 Volume:71 Page:2272-2275
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Bordoni Veronica¹,Sacchi Alessandra¹,Cimini Eleonora¹,Notari Stefania¹,Grassi Germana¹,Tartaglia Eleonora¹,Casetti Rita¹,Giancola Maria Letizia¹,Bevilacqua Nazario¹,Maeurer Markus²³,Zumla Alimuddin⁴⁵,Locatelli Franco⁶,De Benedetti Fabrizio⁶,Palmieri Fabrizio¹,Marchioni Luisa¹,Capobianchi Maria R¹,D’Offizi Gianpiero¹,Petrosillo Nicola¹,Antinori Andrea¹,Nicastri Emanuele¹,Ippolito Giuseppe¹,Agrati Chiara¹

Affiliation:

1. National Institute for Infectious Diseases Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

2. Immunotherapy Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

3. I Med Clinic, University of Mainz, Mainz, Germany

4. Division of Infection and Immunity, University College London, London, United Kingdom

5. National Institute of Health Research Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom

6. Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

Abstract

Abstract Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa577/33462484/ciaa577.pdf

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