Influenza Vaccine Does Not Increase the Risk of Coronavirus or Other Noninfluenza Respiratory Viruses: Retrospective Analysis From Canada, 2010–2011 to 2016–2017

Author:

Skowronski Danuta M12,Zou Macy1,Clarke Quinten1,Chambers Catharine1,Dickinson James A3,Sabaiduc Suzana1,Olsha Romy4,Gubbay Jonathan B45,Drews Steven J67,Charest Hugues8,Winter Anne-Luise4,Jassem Agatha12,Murti Michelle45,Krajden Mel12,De Serres Gaston8910

Affiliation:

1. British Columbia Centre for Disease Control, Vancouver, Canada

2. University of British Columbia, Vancouver, Canada

3. University of Calgary, Calgary, Canada

4. Public Health Ontario, Toronto, Canada

5. University of Toronto, Toronto, Canada

6. Provincial Laboratory for Public Health, Edmonton, Canada

7. University of Alberta, Edmonton, Canada

8. Institut National de Santé Publique du Québec, Quebec City, Canada

9. Laval University, Quebec City, Canada

10. Centre Hospitalier Universitaire de Québec, Quebec City, Canada

Abstract

Abstract Influenza vaccine effectiveness against influenza and noninfluenza respiratory viruses (NIRVs) was assessed by test-negative design using historic datasets of the community-based Canadian Sentinel Practitioner Surveillance Network, spanning 2010–2011 to 2016–2017. Vaccine significantly reduced the risk of influenza illness by >40% with no effect on coronaviruses or other NIRV risk.

Funder

British Columbia Centre for Disease Control, Alberta Health, Public Health Ontario

Ministère de la Santé et des Services Sociaux du Québec

Canadian Institutes of Health Research

Public Health Agency of Canada

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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