Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a-Reference-Cited by-同舟云学术

Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a

Published:2020-02-14 Issue:8 Volume:71 Page:e215-e217
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Popping Stephanie¹,Verwijs Rosanne²,Cuypers Lize³⁴,Claassen Mark A⁵,van den Berk Guido E⁶,De Weggheleire Anja⁷,Arends Joop E⁸,Boerekamps Anne²,Molenkamp Richard¹,Koopmans Marion P¹,Verbon Annelies²,Boucher Charles A B¹,Rijnders Bart J²,van de Vijver David A M C¹,Lauw Fanny,Posthouwer Dirk,Hullegie Sebastiaan,Bierman Wouter,Dofferhof Anthonius,Kootstra Gert Jan,Leyten Eliane,den Hollander Jan,van Kasteren Marjo,Soutekouw Robin,Ammerlaan Heidi,Florence Eric,Lauw Fanny,Posthouwer Dirk,Hullegie Sebastiaan,Bierman Wouter,Dofferhof Anthonius,Kootstra Gert Jan,Leyten Eliane,den Hollander Jan,van Kasteren Marjo,Soutekouw Robin,Ammerlaan Heidi,Florence Eric,

Affiliation:

1. Department of Viroscience, Erasmus Medical Center , University Medical Center, Rotterdam, The Netherlands

2. Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands

3. Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Kristelijke Universiteit Leuven, Leuven, Belgium

4. Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium

5. Department of Internal Medicine and Infectious Diseases, Rijnstate Ziekenhuis, Arnhem, The Netherlands

6. Department of Internal Medicine and Infectious Diseases, Onze lieve vrouwe gasthhuis, Amsterdam, The Netherlands

7. Department of Clinical Science, Institute of Tropical Medicine Antwerp, Antwerp, Belgium

8. Department of Internal Medicine and Infectious Diseases, Universitair Medisch Centrum Utrecht, Utrecht University, Utrecht, The Netherlands

Abstract

Abstract The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

Funder

Health Holland

Gilead Sciences

Fonds voor Wetenschappelijk Onderzoek Vlaanderen

Merck Sharp & Dohme

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa145/32932976/ciaa145.pdf

Reference14 articles.