Systematic Severe Acute Respiratory Syndrome Coronavirus 2 Screening at Hospital Admission in Children: A French Prospective Multicenter Study

Author:

Poline Julie12,Gaschignard Jean134,Leblanc Claire5,Madhi Fouad6,Foucaud Elsa5,Nattes Elodie6,Faye Albert147,Bonacorsi Stéphane348,Mariani Patricia8,Varon Emmanuelle910,Smati-Lafarge Mounira9,Caseris Marion14,Basmaci Romain311,Lachaume Noémie411,Ouldali Naïm14712ORCID

Affiliation:

1. Department of General Pediatrics, Pediatric Infectious Disease and Internal Medicine, Robert Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

2. Université de Paris, Center for Research on Inflammation, Inserm Unité Mixte de Recherche1149, Paris, France

3. Université de Paris, Infection, Antimicrobiens, Modélisation, Evolution, Inserm Unité mixte de Recherche1137, Paris, France

4. Université de Paris, Unité de formation et de recherche de Médecine Paris Nord, Paris, France

5. Department of General Pediatrics, Jean Verdier University Hospital, Assistance Publique-Hôpitaux de Paris, Bondy, France

6. Department of General Pediatrics, Centre Hospitalier Intercommunal de Créteil, Créteil, France

7. Université de Paris, Inserm Unité mixte de recherche 1123, Épidémiologie Clinique, Évaluation économique appliquées aux populations Vulnérables, Paris, France

8. Department of Microbiology, Robert Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

9. Department of Microbiology, Centre Hospitalier Intercommunal de Créteil, Créteil, France

10. National Reference Center for Pneumococci, Créteil, France

11. Service de Pédiatrie-Urgences, Assistance Publique-Hôpitaux de Paris, Hôpital Louis-Mourier, Colombes, France

12. Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France

Abstract

Abstract To assess the relevance of systematic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening of all children admitted to hospital, we conducted a prospective multicenter study including 438 consecutive hospitalized children. A symptom-based SARS-CoV-2 testing strategy failed to identify 45% (95% confidence interval, 24%–68%) of hospitalized children infected by SARS-CoV-2. To limit intrahospital transmission, a systematic screening of children admitted to hospital should be considered.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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