The Mre11p/Rad50p/Xrs2p Complex and the Tel1p Function in a Single Pathway for Telomere Maintenance in Yeast-Reference-Cited by-同舟云学术

The Mre11p/Rad50p/Xrs2p Complex and the Tel1p Function in a Single Pathway for Telomere Maintenance in Yeast

Published:2000-05-01 Issue:1 Volume:155 Page:475-479
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Ritchie Kim B¹,Petes Thomas D¹²

Affiliation:

1. Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280

2. Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280

Abstract

Abstract The Mre11p/Rad50p/Xrs2p complex is involved in the repair of double-strand DNA breaks, nonhomologous end joining, and telomere length regulation. TEL1 is primarily involved in telomere length regulation. By an epistasis analysis, we conclude that Tel1p and the Mre11p/Rad50p/Xrs2p complex function in a single pathway of telomere length regulation.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/155/1/475/42029318/genetics0475.pdf

Reference26 articles.

1. The yeast RAD50 gene encodes a predicted 153-kD protein containing a purine nucleotide-binding domain and two large heptad-repeat regions;Alani;Genetics,1989

2. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination;Alani;Cell,1990

3. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing;Boulton;EMBO J.,1998

4. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast;Brush;Proc. Natl. Acad. Sci. USA,1996

5. MEC1-dependent phosphorylation of Rad9p in response to DNA damage;Emili;Mol. Cell,1998

Cited by 118 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Signification and Application of Mutator and Antimutator Phenotype-Induced Genetic Variations in Evolutionary Adaptation and Cancer Therapeutics;Journal of Microbiology;2023-12

2. Comparison of Two Budding Yeast Disome Model Systems: Similarities, Difference, and Conflict;2022-12-11

3. To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks;Cells;2022-10-14

4. The Bur1 cyclin‐dependent kinase regulates telomere length in Saccharomyces cerevisiae;Yeast;2021-12-02

5. Interplay between Sae2 and Rif2 in the regulation of Mre11-Rad50 activities at DNA ends;Current Opinion in Genetics & Development;2021-12