Affiliation:
1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
Abstract
Abstract
We describe the mutability of the Trp− chromosomal +1 frameshift mutation trpE7999 during nonlethal selection, finding that the appearance of Trp+ revertants behaves similarly to that of episomal Lac+ revertants. In addition, we show that a feature of the Lac+ and Trp+ mutability is the accumulation of Trp+ and Lac+ revertants with additional unselected mutations, most of which are not due to heritable mutators. The cells undergoing nonlethal selection apparently experience an epigenetic change resulting in a subset of bacteria with elevated mutability that often remain hypermutable for the duration of selection. The epigenetic change provoked by nonlethal selection appears to be mediated by a unique function provided by the F'128 episome.
Publisher
Oxford University Press (OUP)
Cited by
43 articles.
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