Evolutionary, Structural and Biochemical Evidence for a New Interaction Site of the Leptin Obesity Protein-Reference-Cited by-同舟云学术

Evolutionary, Structural and Biochemical Evidence for a New Interaction Site of the Leptin Obesity Protein

Published:2003-04-01 Issue:4 Volume:163 Page:1549-1553
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Gaucher Eric A¹,Miyamoto Michael M²,Benner Steven A¹

Affiliation:

1. NASA Astrobiology Institute and Foundation for Applied Molecular Evolution, University of Florida, Gainesville, Florida, 32611-7200

2. Department of Zoology, University of Florida, Gainesville, Florida, 32611-8525

Abstract

Abstract The Leptin protein is central to the regulation of energy metabolism in mammals. By integrating evolutionary, structural, and biochemical information, a surface segment, outside of its known receptor contacts, is predicted as a second interaction site that may help to further define its roles in energy balance and its functional differences between humans and other mammals.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/163/4/1549/42049454/genetics1549.pdf

Reference23 articles.

1. Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: a prediction of the structure of the catalytic domain of protein-kinases;Benner;Adv. Enzyme Regul.,1991

2. Planetary biology: paleontological, geological, and molecular histories of life;Benner;Science,2002

3. Whatever happened to Leptin?;Chicurel;Nature,2000

4. Molecular evolution of Leptin;Doyon;Gen. Comp. Endocrinol.,2001

5. Leptin, Leptin receptors, and the control of body weight;Friedman;Nutr. Rev.,1998

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