Chromosome 14 Contains Determinants That Regulate Susceptibility to Theiler's Virus–Induced Demyelination in the Mouse

Author:

Bureau J-F1,Drescher K M23,Pease L R2,Vikoren T1,Delcroix M1,Zoecklein L23,Brahic M1,Rodriguez M23

Affiliation:

1. Unite des Virus Lents, Centre National de la Recherche Scientifique ERS 572, Institut Pasteur, Paris Cedex 15, France

2. Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901

3. Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901

Abstract

Abstract Theiler's murine encephalomyelitis virus causes a chronic demyelinating disease in susceptible strains of mice that is similar to human multiple sclerosis. Several nonmajor histocompatibility complex–linked genes have been implicated as determinants of susceptibility or resistance to either demyelination or virus persistence. In this study, we used linkage analysis of major histocompatibility complex identical H-2d (DBA/2J × B10.D2) F2 intercross mice to identify loci associated with susceptibility to virus-induced demyelinating disease. In a 20-cM region on chromosome 14, we identified four markers, D14Mit54, D14Mit60, D14Mit61, and D14Mit90 that are significantly associated with demyelination. Because two peaks were identified, one near D14Mit54 and one near D14Mit90, it is possible that two loci in this region are involved in controlling demyelination.

Publisher

Oxford University Press (OUP)

Subject

Genetics

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