Effect of Misoriented Sites on Neutrality Tests With Outgroup-Reference-Cited by-同舟云学术

Effect of Misoriented Sites on Neutrality Tests With Outgroup

Published:2003-11-01 Issue:3 Volume:165 Page:1619-1622
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Baudry Emmanuelle¹,Depaulis Frantz¹

Affiliation:

1. Laboratoire d'Ecologie, Centre National de la Recherche Scientifique UMR 7625-EPHE, Université Pierre et Marie Curie, 75252 Paris Cedex 05, France

Abstract

Abstract Several neutrality tests use outgroups to infer the ancestral and derived states for polymorphism data. However, homoplasy can result in the incorrect inference of the derived variant. We show that empirically derived rates of misorientation strongly influence Fay and Wu's H-test, especially when the sample size is large.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/165/3/1619/42052236/genetics1619.pdf

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