Simultaneous Mining of Linkage and Linkage Disequilibrium to Fine Map Quantitative Trait Loci in Outbred Half-Sib Pedigrees: Revisiting the Location of a Quantitative Trait Locus With Major Effect on Milk Production on Bovine Chromosome 14-Reference-Cited by-同舟云学术

Simultaneous Mining of Linkage and Linkage Disequilibrium to Fine Map Quantitative Trait Loci in Outbred Half-Sib Pedigrees: Revisiting the Location of a Quantitative Trait Locus With Major Effect on Milk Production on Bovine Chromosome 14

Published:2002-05-01 Issue:1 Volume:161 Page:275-287
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Farnir Frédéric¹,Grisart Bernard¹,Coppieters Wouter¹,Riquet Juliette¹,Berzi Paulette¹,Cambisano Nadine¹,Karim Latifa¹,Mni Myriam¹,Moisio Sirja²,Simon Patricia¹,Wagenaar Danny¹,Vilkki Johanna²,Georges Michel¹

Affiliation:

1. Department of Genetics, Faculty of Veterinary Medicine, University of Liège (B43), 4000-Liège, Belgium

2. Animal Production Research, Agricultural Research Centre MTT, 31600 Jokioinen, Finland

Abstract

Abstract A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map a QTL with major effect on milk fat content in a 3-cM marker interval on proximal BTA14. This proximal location is confirmed by applying a haplotype-based association method referred to as recombinant ancestral haplotype analysis. The origin of the discrepancy between the QTL position derived in this work and that of a previous analysis is examined and shown to be due to the existence of distinct marker haplotypes associated with QTL alleles having large substitution effects.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/161/1/275/42047102/genetics0275.pdf

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