GENETIC MODELS FOR THE ANALYSIS OF DATA FROM THE FAMILIES OF IDENTICAL TWINS-Reference-Cited by-同舟云学术

GENETIC MODELS FOR THE ANALYSIS OF DATA FROM THE FAMILIES OF IDENTICAL TWINS

Published:1976-08-01 Issue:4 Volume:83 Page:811-826
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Nance Walter E¹,Corey Linda A²

Affiliation:

1. Department of Human Genetics, Medical College of Virginia, Richmond, Virginia 23298

2. Indiana University School of Medicine, Indianapolis, Indiana

Abstract

ABSTRACT Genetic models are described which exploit the unique relationships that exist within the families of identical twins to obtain weighted least squares estimates of additive, dominance and epistatic components of genetic variance as well as estimates of the contributions of X-linked genes, maternal effects and three sources of environmental variation. Since all of the relationships required to achieve a resolution of these variance components are contained within each family unit, the model would appear to be superior to previous approaches to the analysis of quantitative traits in man.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/genetics/article-pdf/83/4/811/34397444/genetics0811.pdf

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