Affiliation:
1. Department of Zoology, University of North Carolina, Chapel Hill, North Carolina 27514
2. Curriculum in Genetics, University of North Carolina, Chapel Hill, North Carolina 27514
Abstract
ABSTRACT
EMS-induced "null" and low activity alleles for 6-phosphogluconate dehydrogenase were characterized with respect to enzymatic activity, relative viability, fertility, and the effective lethal phase. It was determined that flies hemizygous and homozygous for the low activity allele, Pgd -, possessed a depressed developmental rate, diminished viability, and loss of female fertility. Heterozygotes for Pgd - and a deficiency for Pgd + were lethal. The "null" activity allele demonstrated a lethal phenotype in both the hemizygous and homozygous condition. The effective lethal phase for the "null" allele occurs during late embryonic development (20-22 hr).
Publisher
Oxford University Press (OUP)
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献