1. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto M5T 3L9, Ontario , Canada
2. Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute , Toronto M5G 1X8, Ontario , Canada
3. Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto , Toronto M5T 3M7, Ontario , Canada
4. Department of Biostatistics, Princess Margaret Cancer Centre , Toronto M5G 2C1, Ontario , Canada
5. Department of Statistical Sciences, University of Toronto , Toronto M5S 3G3, Ontario , Canada
6. Department of Epidemiology and Biostatistics, Western University , London N6A 5C1, Ontario , Canada