Affiliation:
1. Laboratory of Radiobiology, University of California, San Francisco, California 94122
Abstract
ABSTRACT
A formula, based on the Poisson distribution of radiation-induced chromosomal deletions, was derived to predict the frequency of transmission of acentric fragments between subsequent mitoses. The frequency of deletions observed in the i th + 1 division subsequent to fragment distribution at the i th division anaphase is independent of the cell death resulting from fragment loss. Further, the transmission frequency of chromosome acentric fragments is mathematically equal to the fragment frequency observed in the i th + 1 generation divided by the mean fragment frequency in the i th generation. The formula was also extended to chromatid deletions.
Publisher
Oxford University Press (OUP)
Cited by
3 articles.
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