α-HYDROXYACID OXIDASE GENETICS IN THE MOUSE: EVIDENCE FOR TWO GENETIC LOCI AND A TETRAMERIC SUBUNIT STRUCTURE FOR THE LIVER ISOZYME

Abstract

ABSTRACT We have examined a polymorphism for liver GOX in inbred strains of the mouse Mus musculus. Genetic studies demonstrated that the two phenotypes for this enzyme present in BALB/C and NZC parental strains segregated as though they were controlled by codominant alleles at a single autosomal locus (GOX) which mapped closely to the agouti locus in linkage group V. Kidney HAOX activity is invariant in these inbred strains and is encoded by a separate genetic locus designated HAOX. BALB/C × NZC F1 hybrid mice exhibited three intermediate forms of liver GOX activity, in addition to the parental enzymes, which is consistent with a tetrameric subunit structure.