α-HYDROXYACID OXIDASE GENETICS IN THE MOUSE: EVIDENCE FOR TWO GENETIC LOCI AND A TETRAMERIC SUBUNIT STRUCTURE FOR THE LIVER ISOZYME

Author:

Duley John1,Holmes Roger S1

Affiliation:

1. Department of Biochemistry, La Trobe University, Bundoora, 3083, Victoria, Australia

Abstract

ABSTRACT We have examined a polymorphism for liver GOX in inbred strains of the mouse Mus musculus. Genetic studies demonstrated that the two phenotypes for this enzyme present in BALB/C and NZC parental strains segregated as though they were controlled by codominant alleles at a single autosomal locus (GOX) which mapped closely to the agouti locus in linkage group V. Kidney HAOX activity is invariant in these inbred strains and is encoded by a separate genetic locus designated HAOX. BALB/C × NZC F1 hybrid mice exhibited three intermediate forms of liver GOX activity, in addition to the parental enzymes, which is consistent with a tetrameric subunit structure.

Publisher

Oxford University Press (OUP)

Subject

Genetics

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1. Be different—The diversity of peroxisomes in the animal kingdom;Biochimica et Biophysica Acta (BBA) - Molecular Cell Research;2010-08

2. Involvement of Ionizable Groups in Catalysis of Human Liver Glycolate Oxidase;Journal of Biological Chemistry;2009-11

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4. Purification and characterization of recombinant human liver glycolate oxidase;Archives of Biochemistry and Biophysics;2007-09

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