ON THE IDENTIFICATION OF THE ROSY LOCUS DNA IN DROSOPHILA MELANOGASTER: INTRAGENIC RECOMBINATION MAPPING OF MUTATIONS ASSOCIATED WITH INSERTIONS AND DELETIONS

Author:

Clark S H1,McCarron M1,Love C1,Chovnick A1

Affiliation:

1. Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut 06268

Abstract

ABSTRACT DNA extracts of several rosy-mutation-bearing strains were associated with large insertions and deletions in a defined region of the molecular map believed to include the rosy locus DNA. Large-scale, intragenic mapping experiments were carried out that localized these mutations within the boundaries of the previously defined rosy locus structural element. Molecular characterization of the wild-type recombinants provides conclusive evidence that the rosy locus DNA is localized to the DNA segment marked by these lesions.—One of the mutations, ry  2101, arose from a P-M hybrid dysgenesis experiment and is associated with a copia insertion. Experiments are described which suggest that copia mobilizes in response to P-M hybrid dysgenesis.—Relevance of the data to recombination in higher organisms is considered.

Publisher

Oxford University Press (OUP)

Subject

Genetics

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