DELETIONS OF THE ISO-1-CYTOCHROME c AND ADJACENT GENES OF YEAST: DISCOVERY OF THE OSM1 GENE CONTROLLING OSMOTIC SENSITIVITY

Abstract

ABSTRACT Some of the deletions in the yeast Saccharomyces cerevisiae that encompass the CYC1 gene, which determines iso-1-cytochrome c, extend into the OSM1 gene, causing inhibition of growth on hypertonic media, and into the RAD7 gene, causing sensitivity to UV light. Two deletions (cyc1-363 and cyc1-367) encompass only the CYC1 gene, two deletions (cyc1-366 and cyc1-368) encompass the CYC1 and OSM1 genes, three deletions (cyc1-1, cyc1-364 and cyc1-365) encompass the CYC1, OSM1 and RAD7 genes, while none of the deletions extend into the closely linked SUP4 gene.