The Effect of Population History on the Lengths of Ancestral Chromosome Segments

Author:

Chapman Nicola H1,Thompson Elizabeth A2

Affiliation:

1. Division of Medical Genetics, University of Washington, Seattle, Washington 98195

2. Department of Statistics, University of Washington, Seattle, Washington 98195

Abstract

Abstract An isolated population is a group of individuals who are descended from a founding population who lived some time ago. If the founding individuals are assumed to be noninbred and unrelated, a chromosome sampled from the population can be represented as a mosaic of segments of the original ancestral types. A population in which chromosomes are made up of a few long segments will exhibit linkage disequilibrium due to founder effect over longer distances than a population in which the chromosomes are made up of many short segments. We study the length of intact ancestral segments by obtaining the expected number of junctions (points where DNA of two distinct ancestral types meet) in a chromosome. Assuming random mating, we study analytically the effects of population age, growth patterns, and internal structure on the expected number of junctions in a chromosome. We demonstrate that the type of growth a population has experienced can influence the expected number of junctions, as can population subdivision. These effects are substantial only when population sizes are very small. We also develop an approximation to the variance of the number of junctions and show that the variance is large.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference12 articles.

1. Chapman N H , 2001  Genome descent in isolated populations. Ph.D. Thesis, University of Washington, Seattle, WA.

2. Linkage disequilibrium mapping: the role of population history, size and structure;Chapman,2001

3. Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility;Chapman;Am. J. Hum. Genet.,1998

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