False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders-Reference-Cited by-同舟云学术

False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders

Published:2003-06-01 Issue:2 Volume:164 Page:829-833
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Sabatti Chiara¹,Service Susan²,Freimer Nelson²

Affiliation:

1. Departments of Human Genetics and Statistics, University of California, Los Angeles, California 90095-7088

2. Center for Neurobehavioral Genetics, Neuropsychiatric Institute, and Departments of Psychiatry and Human Genetics, University of California, Los Angeles, California 90095-1761

Abstract

Abstract We explore the implications of the false discovery rate (FDR) controlling procedure in disease gene mapping. With the aid of simulations, we show how, under models commonly used, the simple step-down procedure introduced by Benjamini and Hochberg controls the FDR for the dependent tests on which linkage and association genome screens are based. This adaptive multiple comparison procedure may offer an important tool for mapping susceptibility genes for complex diseases.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/164/2/829/42052575/genetics0829.pdf

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