Affiliation:
1. NMS Labs, 200 Welsh Rd, Willow Grove, PA 19044, USA
Abstract
Abstract
The purpose of this study was to examine the impact of 59 novel psychoactive compounds on common enzyme-linked immunosorbent assay (ELISA) testing kits. Concentrations above and below the individual kit reporting limits in each class were measured. Compounds that exhibited cross-reactivity were then spiked individually using a seven-point response curve to determine the level of cross-reactivity. Diclazepam, delorazepam, phenazepam, flualprazolam, bromazolam, adinazolam, 3-methoxy-PCP, 3-hydroxy-PCP (3-OH-PCP), phenylfentanyl, para-methylacetylfentanyl and para-fluorofuranylfentanyl were determined to cross-react in the respective kits below. Herein, we detail the cross-reactivity that was observed with the above novel psychoactive substances on Immunalysis Benzodiazepine (BEN), Phencyclidine (PCP), Fentanyl (FEN), Buprenorphine (BUP), Opiates (OPI) and Oxycodone (OXY) Direct ELISA kits.
Publisher
Oxford University Press (OUP)
Subject
Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology,Environmental Chemistry,Analytical Chemistry
Reference16 articles.
1. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA);European Drug Report: Trends and Developments 2019,2019
2. Drug Enforcement Administration’s (DEA) Intelligence Program;2020 National Drug Threat Assessment (NDTA),2021
3. Immunalysis Corporation;Enzyme Linked Immunosorbent Assay (ELISA),2021
4. False-positive interferences of common urine drug screen immunoassays: a review;Saitman;Journal of Analytical Toxicology,2014
5. Chemoinformatic methods for predicting interference in drug of abuse/toxicology immunoassays;Krasowski;Clinical Chemistry,2009
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献