Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease

Author:

Roberts Rebecca L1,Wallace Mary C1,Seinen Margien L23,van Bodegraven Adriaan A23,Krishnaprasad Krupa4,Jones Gregory T1,van Rij Andre M1,Baird Angela5,Lawrance Ian C56,Prosser Ruth7,Bampton Peter7,Grafton Rachel8,Simms Lisa A4,Studd Corrie9,Bell Sally J9,Kennedy Martin A10,Halliwell Jacob11,Gearry Richard B12,Radford-Smith Graham413,Andrews Jane M8,McHugh Patrick C11,Barclay Murray L12ORCID

Affiliation:

1. Department of Surgical Sciences (Dunedin), University of Otago, Otago, New Zealand

2. Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, the Netherlands

3. Department of Internal Medicine, Gastroenterology and Geriatrics, Atrium-ORBIS Medical Center, Heerlen-Sittard, the Netherlands

4. QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

5. Centre for Inflammatory Bowel Disease, Saint John of God Hospital, Subiaco, WA, Australia

6. Harry Perkins Institute of Medical Research, School of Medicine and Pharmacology, University of Western Australia, Murdoch, WA, Australia

7. Flinders Medical Centre, Flinders University of South Australia, Bedford Park, South Australia, Australia

8. Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia

9. Department of Gastroenterology, St Vincent’s Hospital, Melbourne, Victoria, Australia

10. Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand

11. Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, UK

12. Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand

13. Department of Gastroenterology, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

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