Reversing Ongoing Chronic Intestinal Inflammation and Fibrosis by Sustained Block of IL-12 and IL-23 Using a Vaccine in Mice

Author:

Guan Qingdong1234,Weiss Carolyn R12,Wang Shuhe5,Qing Gefei6,Yang Xi15,Warrington Richard J17,Bernstein Charles N7,Peng Zhikang12

Affiliation:

1. Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada

2. Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada

3. Cellular Therapy Laboratory, CancerCare Manitoba, Winnipeg, Manitoba, Canada

4. The Institute of Clinical Research and Translational Medicine, Gansu Provincial Hospital, Lanzhou Shi, Gansu Sheng, China

5. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

6. Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada

7. Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Funder

Canadian Institutes of Health Research

Children Hospital Research Institute of Manitoba

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Reference47 articles.

1. Inflammatory bowel disease;Kaser;Annu Rev Immunol,2010

2. Future directions in inflammatory bowel disease management;D’Haens;J Crohns Colitis,2014

3. IL-23/IL-17 axis in IBD;Sarra;Inflamm Bowel Dis,2010

4. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases;Strober;Gastroenterology,2011

5. Immunopathogenesis of IBD: current state of the art;de Souza;Nat Rev Gastroenterol Hepatol,2016

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