Sucralose Increased Susceptibility to Colitis in Rats

Author:

Wang Xiuhong12,Guo Junyu123,Liu Yuanli12,Yu Hengyuan12,Qin Xiaofa4

Affiliation:

1. Department of Biochemistry, Heilongjiang Provincial Science and Technology Innovation Team in Higher Education Institutes for Infection and Immunity, Harbin Medical University, Harbin, China

2. Department of Molecular Biology, Heilongjiang Provincial Science and Technology Innovation Team in Higher Education Institutes for Infection and Immunity, Harbin Medical University, Harbin, China

3. Department of Qingdao University Affiliated Hospital, Qingdao, Shandong

4. GI Biopharma Inc., Westfield, New Jersey

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Reference4 articles.

1. The artificial sweetener splenda promotes gut proteobacteria, dysbiosis, and myeloperoxidase reactivity in Crohn’s disease–like ileitis;Rodriguez-Palacios;Inflamm Bowel Dis,2018

2. Increased digestive proteases and decreased β-glucuronidase in feces of rats treated with sucralose and saccharin-another critical evidence that these dietary chemicals may be important causative factors for inflammatory bowel disease;Li;Inflamm Bowel Dis,2016

3. Unconjugated bilirubin ameliorates the inflammation and digestive protease increase in TNBS-induced colitis;Zhou;Mol Med Rep,2017

4. Etiology of inflammatory bowel disease: a unified hypothesis;Qin;World J Gastroenterol,2012

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