Affiliation:
1. Kyushu University Division of Allergy and Immunology, Medical Institute of Bioregulation, , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Abstract
AbstractImmune reactions in the brain, the most complex organ that directly or indirectly regulates almost every part of the body and its actions, need to be tightly regulated. Recent findings in the field of neuroimmunology have enhanced our understanding of immune cells not only inside the brain but also in adjacent tissues. Multiple types of immune cells exist and are active in neighboring border tissues, even in the steady state. In addition, advances in technology have allowed researchers to characterize a broad range of cell types, including stromal cells that support immune reactions. This review presents a short overview of the roles of the immune system in the brain during health and disease, with focus on adaptive immunity and anatomical sites of action. We also discuss potential roles of stromal cells.
Publisher
Oxford University Press (OUP)
Subject
Molecular Biology,Biochemistry,General Medicine
Reference76 articles.
1. The blood-brain barrier;Daneman;Cold Spring Harb. Perspect. Biol.,2015
2. Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye;Medawar;Br. J. Exp. Pathol.,1948
3. The cellular reactions to heterologous, homologous and autologous skin implanted into brain;Ridley;J. Pathol.,1969
4. Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmette-Guerin;Matyszak;Neuroscience,1995
5. What is immune privilege (not)?;Galea;Trends Immunol.,2007